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(R)-(4,4-BIS(3-METHYL-2-THIENYL)-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID, HYDROCHLORIDE
Descriptors Found:
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DeCS
Descriptor
English
:
Tiagabine
Descriptor
Spanish
:
tiagabina
Descriptor
Portuguese
:
Tiagabina
Synonyms
English
:
(R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride
Gabitril
N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid
NO 328
NO 329
NO-328
NO-329
Tiagabine Hydrochloride
Tiagabine, (S)-isomer
Tree Number:
D03.066.566.500
D03.383.621.566.500
Definition
English
:
A nipecotic acid derivative that acts as a GABA uptake inhibitor and anticonvulsant agent. It is used in the treatment of
EPILEPSY
, for refractory PARTIAL
SEIZURES.
Pharmacological Action:
Anticonvulsants
GABA Uptake Inhibitors
History Note
English
:
2019 (1989)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
57799
Unique Identifier:
D000078308
Occurrence in VHL
:
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DeCS